What it is
Study of the CD3+CD4+ Th1, Th2 and Th17 lymphocyte subsets, identified by intracellular staining for IFNg, IL4 and IL17 respectively, and measurement of regulatory T cells (Treg) by surface staining (CD4+CD127low), to assess the polarisation of the adaptive immune response in blood. Reported as relative results (percentage of each population of total lymphocytes) and as absolute values (cell count per unit volume). Intracellular staining after culture is the only methodology tested in the clinical trials that have linked an increased Th1/Th2 ratio to repeated implantation failure, showing the benefit of immunomodulatory treatments: Tacrolimus treatment in women with repeated implantation failures - PubMed (nih.gov) Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF) - PubMed (nih.gov) Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures - PubMed (nih.gov)
- Sample
- Whole blood (heparin) · Whole blood (EDTA)
- Laboratory
- Reference Laboratory (may vary depending on the collection point)
- Restricted times
- Only from Monday to Wednesday, until 13:00, and never on the day before a public holiday in the laboratory's city. When you order it, we only offer valid days and times.
Other methods for this test
- 109 Th1/Th2 ratio of CD4+ T lymphocytes · 180,00 €
If your doctor does not specify the method, upload their report and we will review it.